Research

Current research areas

Developing human-relevant, in vitro, biomimetic models of chronic wound infections for clinical and translational applications

Using a combination of bioengineering, microengineering, microscopy, cell and microbial culture, our research focuses on recapitulating the key elements of the chronic wound infection state in an in vitro platform. This platform will provide insights into the dynamic wound infection microenvironment and will be leveraged to develop diagnostic and therapeutic approaches for chronic wound infections.

Funded by the Ramalingaswami Re-entry Fellowship, Department of Biotechnology, Govt. of India

Developing a biomimetic wound infection bed platform to accelerate pre-clinical testing of infection therapeutics

We aim to develop an in vitro model of the wound infection state that lends itself well for high-throughput, accelerated, precise, reproducible, accurate and low-cost testing and development of infection therapeutics. This will not only serve as an alternative to animal testing, but also open a new paradigm in infection therapeutics development with the 'Test more, Fail fast' approach.

Funded by the Innovative Young Biotechnologist Award (IYBA), Department of Biotechnology, Govt. of India

Dissecting host-microbial dynamics in chronic wound infections, with special reference to immune cell dynamics

Using an in vitro, biomimetic model of the chronic wound-bed capillary interface, our research will employ advanced transcriptomics to study immune cell (such as neutrophils and macrophages) signaling and expression, under selective and precise conditions of the chronic wound infection state. This will provide invaluable insights into immune cell functioning and potential therapeutics in the chronic wound infection state.

Long-term characterization of microbial populations from patients with chronic wound infection states

We are starting a research project that focuses on long-term phenotypic, metagenomic and molecular characterization of microbial populations from patients with chronic wound infections. We are looking to collaborate with clinicians/clinical microbiologists/infectious disease specialists/surgeons and academic faculty. If this interests you, please get in touch!

We are looking to write a collaborative grant on this project.