The wound infection lab

We aim to gain a better understanding of the complex wound infection microenvironment, and enable composite, precision-based and personalized therapeutic approaches.

Normal wound healing is a well-orchestrated process, however, microbial infections are the single-most important cause of delayed wound healing.

The sequential phases of normal wound healing

Microbial infection typically occurs in the inflammation-proliferation phase, leading to chronic, non-healing wounds.

Infected wounds get arrested in a prolonged phase of inflammation-proliferation with dynamic interactions between host cells, microbes, immune cells, and growth factors across the wound-bed capillary interface.

The dynamic wound bed-capillary interface

In wound infections, an intricate communicative network exists between host cells, extracellular matrix, microbes, and immune cells, regulated by complex chemical and mechanical cues.

Left image: Modified from Gurtner, G. C., Werner, S., Barrandon, Y. & Longaker, M. T. Wound repair and regeneration. Nature(2008) 453, 314-21.

The prioritization of infected wounds has shifted from a co-morbid condition to a silent global epidemic with huge public health and economic impact.

it is imperative to develop effective strategies for the prevention and management of chronic wound infections