The wound infection lab
The wound infection lab
We aim to gain a better understanding of the complex wound infection microenvironment, and enable composite, precision-based and personalized therapeutic approaches.
We aim to gain a better understanding of the complex wound infection microenvironment, and enable composite, precision-based and personalized therapeutic approaches.
Normal wound healing is a well-orchestrated process, however, microbial infections are the single-most important cause of delayed wound healing.
Normal wound healing is a well-orchestrated process, however, microbial infections are the single-most important cause of delayed wound healing.
The sequential phases of normal wound healing
The sequential phases of normal wound healing
Microbial infection typically occurs in the inflammation-proliferation phase, leading to chronic, non-healing wounds.
Infected wounds get arrested in a prolonged phase of inflammation-proliferation with dynamic interactions between host cells, microbes, immune cells, and growth factors across the wound-bed capillary interface.
Infected wounds get arrested in a prolonged phase of inflammation-proliferation with dynamic interactions between host cells, microbes, immune cells, and growth factors across the wound-bed capillary interface.
The dynamic wound bed-capillary interface
The dynamic wound bed-capillary interface
In wound infections, an intricate communicative network exists between host cells, extracellular matrix, microbes, and immune cells, regulated by complex chemical and mechanical cues.
Left image: Modified from Gurtner, G. C., Werner, S., Barrandon, Y. & Longaker, M. T. Wound repair and regeneration. Nature(2008) 453, 314-21.
The prioritization of infected wounds has shifted from a co-morbid condition to a silent global epidemic with huge public health and economic impact.
The prioritization of infected wounds has shifted from a co-morbid condition to a silent global epidemic with huge public health and economic impact.
it is imperative to develop effective strategies for the prevention and management of chronic wound infections
it is imperative to develop effective strategies for the prevention and management of chronic wound infections