We aim to gain a better understanding of the complex wound infection MICRO-ENVIRONMENT, and enable composite, precision-based and personalized therapeutic approaches.
Normal wound healing is a well-orchestrated process, however, microbial infections are the single-most important cause of delayed wound healing.
The sequential phases of normal wound healing
Microbial infection typically occurs in the inflammation-proliferation phase, leading to chronic, non-healing wounds.
Infected wounds get arrested in a prolonged phase of inflammation-proliferation with dynamic interactions between host cells, microbes, immune cells, and growth factors across the wound-bed capillary interface.
The dynamic wound bed-capillary interface
In wound infections, an intricate communicative network exists between host cells, extracellular matrix, microbes, and immune cells, regulated by complex chemical and mechanical cues.